Rheological characterisation of collagenic gels for biomedical applications

Rheological characterisation of collagenic gels for biomedical applications

Autori: G. La Sala, V. Miceli, D. Gabriele, B. de Cindio
Presentato al: Southern Europe Conference on Rheology
Anno: 1999
Volume: 2 - Issue: Unico
Casa Editrice: SIR-Cuen Napoli
Lingua: English

Abstract
Collagen is formed by rather long chains (about 280 nm) of protein shaped as fibres that are widely aggregate along both the longitudinal and transversal directions. It is often used in the biomedical field as a matrix for vascular prosthesis for different reasons, but especially because by impregnating prosthesis by collagen it is possible to obtain a temporary blood impermeability that avoids in such a way undesired blood flux during prosthesis implantation. Cattle tendons are the raw material used to prepare the so called native collagen, therefore very often an inherent variability is expected between different stocks of different suppliers. A partial chemical denaturing by thermal treatment of the native collagen is necessary to making possible the spreading and a good impregnation. However this treatment should not be so strong, because it is required to maintain good mechanical properties, i.e. flexibility and resistance to traction. The final result should be a suspension of denatured collagen capable to be pushed into the prosthesis and to completely impregnate it. Afterward the prosthesis is dried and the fixation is made, where bonds are formed between collagen fibres thus generating a solid-like structure enough stable to the enzyme activity responsible of the “in vivo” digestion reaction.

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XIX Italian Society of Rheology Conference

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The Italian Society of Rheology (SIR) organizes every two years the Italian Rheology Conference, which is the meeting point of the National and International rheological community to promote knowledge and discuss research in the field of rheology. The Conference consists of keynote lectures, oral communications and posters on topics related to all the thematic areas of rheology. The XIX edition will be held in the conference rooms of Plesso Belmeloro, in the city centre of Bologna, in June 16th-19th, 2026. Book your accommodation in Bologna well in advance, the city is a famous tourist destination and has limited availability of accommodations!

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